Interior Secretary Ryan Zinke is from Montana. He is, if my statistics are correct, the first US cabinet officer ever from Montana. (FDR was going to have one, but he died just before taking office.)
My statistics also say that this marks 48 states that have provided cabinet officers. The two states bereft of cabinet representation throughout US history are South Dakota (Obama was going to have one, but he had to withdraw) and Nevada.
He is also the first US cabinet officer to begin with a Z, thus completing that set except for Q and X.